Endocrine Abstracts

Bariatric surgery is known to improve obesity-induced systemic inflammation and glucose homeostasis, however, the exact mechanisms behind this effect are not fully understood. We have previously shown that Sodium Glucose Transporter 2 (SGLT2) is significantly inhibited in the kidney cortex following Vertical Sleeve Gastrectomy (VSG), causing a reduction in renal glucose reabsorption. In this study, we hypothesize that the observed post-operative reduction of SGLT2 is controlle...

Currently, most Type 2 Diabetes (T2D) treatments are targeted for the mitigation of the disease rather than remission. It has been previously demonstrated that T2D remission post-bariatric surgery in mice is independent of weight loss, indicating a metabolic mechanism. One avenue that remains largely unexplored is the role of cortisol, a hormone secreted from the adrenal cortex, dysregulation of which is linked to insulin resistance and obesity. The enzyme 11β-Hydroxyster...

Background: Sodium-glucose cotransporter-2 (SGLT2) inhibitors are a new class of oral anti-diabetic medications that improve glycaemia by reducing the amount of glucose being absorbed in the kidneys. SGLT2 inhibitors have been proven to improve blood pressure, cardiovascular health and kidney disease. Despite their beneficial clinical effects, their exact mechanism of action is not fully explored. The aim of this project was to investigate the effect of SGLT2 ...